| Autor: |
Tsantoulas, Christoforos, Laínez, Sergio, Wong, Sara, Mehta, Ishita, Vilar, Bruno, McNaughton, Peter A. |
| Předmět: |
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| Zdroj: |
Science Translational Medicine; 9/27/2017, Vol. 9 Issue 409, p1-13, 13p |
| Abstrakt: |
The article looks at a study which discusses the role of hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) ion channels in chronic pain by showing in a mouse model of diabetic neuropathy. It mentions pharmacological or genetic block of HCN2 activity exerts potent analgesic effects in animal models of both type 1 and type 2 diabetes. It also mentions intracellular cyclic adenosine monophosphate (cAMP), is increased in somatosensory neurons in an animal model of painful diabetes. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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