[Ionization energy and glycoside bond rupture energy of nucleosides, suppressing the reproduction of the human immunodeficiency virus (HIV)].
| Autor: | Orlov VM, Pustobaev VN |
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| Jazyk: | ruština |
| Zdroj: | Molekuliarnaia biologiia [Mol Biol (Mosk)] 1993 Mar-Apr; Vol. 27 (2), pp. 316-9. |
| Abstrakt: | By photoionization mass spectrometry the energy characteristics were investigated for a series of nucleosides whose triphosphates possess anti-HIV activity. The electron-donor ability (a value reciprocal to ionization energy) does not correlate with the biological activity of corresponding nucleotides. The energy of glycoside bond rupture depended on modification in deoxyribose. |
| Databáze: | MEDLINE |
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