[Ionization energy and glycoside bond rupture energy of nucleosides, suppressing the reproduction of the human immunodeficiency virus (HIV)].

Autor: Orlov VM, Pustobaev VN
Jazyk: ruština
Zdroj: Molekuliarnaia biologiia [Mol Biol (Mosk)] 1993 Mar-Apr; Vol. 27 (2), pp. 316-9.
Abstrakt: By photoionization mass spectrometry the energy characteristics were investigated for a series of nucleosides whose triphosphates possess anti-HIV activity. The electron-donor ability (a value reciprocal to ionization energy) does not correlate with the biological activity of corresponding nucleotides. The energy of glycoside bond rupture depended on modification in deoxyribose.
Databáze: MEDLINE