[Aspartate aminotransferase activity in the brain and spinal cord in acute and chronic alcoholic intoxication].
| Autor: | Veksler IaI, Magomedova KM |
|---|---|
| Jazyk: | ruština |
| Zdroj: | Voprosy meditsinskoi khimii [Vopr Med Khim] 1980 Jul-Aug; Vol. 26 (4), pp. 438-42. |
| Abstrakt: | Resynthesis of aspartate via glutamate was decreased 6-8-fold in rat brain spinal cord tissues due to distinct inhibition of aspartate aminotransferase in acute alcohol intoxication. Consumption of glutamic acid was distinctly increased 1.5-2-fold in tissues of the central nervous system but its metabolism was altered. Normalization occurred within 12-24 hrs after the intake of alcohol. In the state of chronic alcohol intoxication the enzymatic activity was marked increased in brain and spinal cord; in this case the response to a single alcohol administration was altered as compared with acute alcohol intoxication. |
| Databáze: | MEDLINE |
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