Damage to DNA induces expression of the ruv gene of Escherichia coli.
| Autor: | Shurvinton CE, Lloyd RG |
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| Jazyk: | angličtina |
| Zdroj: | Molecular & general genetics : MGG [Mol Gen Genet] 1982; Vol. 185 (2), pp. 352-5. |
| DOI: | 10.1007/BF00330811 |
| Abstrakt: | Regulation of the ruv gene of E. coli was studied using phage Mud (Ap lac) to obtain a fusion of the lac genes to the ruv promoter. Beta-galactosidase synthesis in the ruv-lac fusion strain was induced by mitomycin C and other agents that damage DNA. The induction of beta-galactosidase could be altered by mutations either in lexA or recA from which it is concluded that ruv is regulated by lexA repressor. A possible function of ruv in promoting cell recovery following damage to DNA is discussed. |
| Databáze: | MEDLINE |
| Externí odkaz: |
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