Methyldopa liver damage.

Autor: Toghill PJ, Smith PG, Benton P, Brown RC, Matthews HL
Jazyk: angličtina
Zdroj: British medical journal [Br Med J] 1974 Aug 31; Vol. 3 (5930), pp. 545-8.
DOI: 10.1136/bmj.3.5930.545
Abstrakt: Twenty patients are described in whom liver damage appeared to be directly related to the administration of methyldopa. Sixteen had hepatitic syndromes from which they recovered on stopping methyldopa; four of these patients had recurrences of jaundice after a second course of the drug. Features suggestive of active chronic hepatitis were found in two patients. There were two deaths attributed to methyldopa, one of these being in a patient with pre-existing undiagnosed macronodular cirrhosis.
Databáze: MEDLINE