Mechanistic insights into the basis of widespread RNA localization.

Autor: Chekulaeva M; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany. marina.chekulaeva@mdc-berlin.de.
Jazyk: angličtina
Zdroj: Nature cell biology [Nat Cell Biol] 2024 Jul; Vol. 26 (7), pp. 1037-1046. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1038/s41556-024-01444-5
Abstrakt: The importance of subcellular mRNA localization is well established, but the underlying mechanisms mostly remain an enigma. Early studies suggested that specific mRNA sequences recruit RNA-binding proteins (RBPs) to regulate mRNA localization. However, despite the observation of thousands of localized mRNAs, only a handful of these sequences and RBPs have been identified. This suggests the existence of alternative, and possibly predominant, mechanisms for mRNA localization. Here I re-examine currently described mRNA localization mechanisms and explore alternative models that could account for its widespread occurrence.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
Externí odkaz: