Mechanistic insights into the basis of widespread RNA localization.
Autor: | Chekulaeva M; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany. marina.chekulaeva@mdc-berlin.de. |
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Jazyk: | angličtina |
Zdroj: | Nature cell biology [Nat Cell Biol] 2024 Jul; Vol. 26 (7), pp. 1037-1046. Date of Electronic Publication: 2024 Jul 02. |
DOI: | 10.1038/s41556-024-01444-5 |
Abstrakt: | The importance of subcellular mRNA localization is well established, but the underlying mechanisms mostly remain an enigma. Early studies suggested that specific mRNA sequences recruit RNA-binding proteins (RBPs) to regulate mRNA localization. However, despite the observation of thousands of localized mRNAs, only a handful of these sequences and RBPs have been identified. This suggests the existence of alternative, and possibly predominant, mechanisms for mRNA localization. Here I re-examine currently described mRNA localization mechanisms and explore alternative models that could account for its widespread occurrence. (© 2024. Springer Nature Limited.) |
Databáze: | MEDLINE |
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