The Search for Drugs Derived from Natural Products for Toxoplasma gondii Infection Treatment in the Last 20 Years - A Systematic Review.
| Autor: | Marques-Santos F; FundaçãoOswaldo Cruz - Fiocruz, Instituto Oswaldo Cruz, Laboratório de Toxoplasmose e outras Protozooses, Rio de Janeiro, RJ, Brasil., Faria RX; Fundação Oswaldo Cruz, Fiocruz, Instituto Oswaldo Cruz, Laboratório de Avaliação e Promoção da Saúde Ambiental, Rio de Janeiro, RJ, Brasil., Amendoeira MRR; FundaçãoOswaldo Cruz - Fiocruz, Instituto Oswaldo Cruz, Laboratório de Toxoplasmose e outras Protozooses, Rio de Janeiro, RJ, Brasil. |
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| Jazyk: | angličtina |
| Zdroj: | Current topics in medicinal chemistry [Curr Top Med Chem] 2024 Jun 28. Date of Electronic Publication: 2024 Jun 28. |
| DOI: | 10.2174/0115680266299409240606062235 |
| Abstrakt: | Introduction: Toxoplasmosis is a worldwide distributed zoonosis caused by Toxo-plasma gondii (T. gondii), an obligate intracellular protozoan. The infection in immunocompetent hosts usually progresses with mild or no symptoms. However, in immunocompromised individu-als, this disease can cause severe or fatal symptoms. Method: Sulfadiazine and pyrimethamine are two drugs used as standard therapies for human toxoplasmosis. Although they do not cause chronic infection, they may cause hematological tox-icity, hypersensitivity, intolerance, teratogenic effects, gastrointestinal disorders, and bone mar-row suppression. Result: The limited effect, significant toxicity, and emerging resistance to current drugs available to treat T. gondii infections require investigating other effective, nontoxic, and well-tolerated al-ternatives. Medicinal plants are, traditionally, the most promising sources used to treat infectious diseases. Conclusion: This review provides data on new therapeutic and prophylactic methods for T. gondii infection based on the use of extracts and/or compounds derived from natural products, which have been reported to be useful as alternative treatment options in the last 20 years. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Databáze: | MEDLINE |
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