The Search for Drugs Derived from Natural Products for Toxoplasma gondii Infection Treatment in the Last 20 Years - A Systematic Review.
| Autor: | Marques-Santos F; FundaçãoOswaldo Cruz - Fiocruz, Instituto Oswaldo Cruz, Laboratório de Toxoplasmose e outras Protozooses, Rio de Janeiro, RJ, Brasil., Faria RX; Fundação Oswaldo Cruz, Fiocruz, Instituto Oswaldo Cruz, Laboratório de Avaliação e Promoção da Saúde Ambiental, Rio de Janeiro, RJ, Brasil., Amendoeira MRR; FundaçãoOswaldo Cruz - Fiocruz, Instituto Oswaldo Cruz, Laboratório de Toxoplasmose e outras Protozooses, Rio de Janeiro, RJ, Brasil. |
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| Jazyk: | angličtina |
| Zdroj: | Current topics in medicinal chemistry [Curr Top Med Chem] 2024; Vol. 24 (22), pp. 1960-1999. |
| DOI: | 10.2174/0115680266299409240606062235 |
| Abstrakt: | Introduction: Toxoplasmosis is a worldwide distributed zoonosis caused by Toxoplasma gondii (T. gondii ), an obligate intracellular protozoan. The infection in immunocompetent hosts usually progresses with mild or no symptoms. However, in immunocompromised individuals, this disease can cause severe or fatal symptoms. Method: Sulfadiazine and pyrimethamine are two drugs used as standard therapies for human toxoplasmosis. Although they do not cause chronic infection, they may cause hematological toxicity, hypersensitivity, intolerance, teratogenic effects, gastrointestinal disorders, and bone marrow suppression. Results: The limited effect, significant toxicity, and emerging resistance to current drugs available to treat T. gondii infections require investigating other effective, nontoxic, and well-tolerated alternatives. Medicinal plants are, traditionally, the most promising sources used to treat infectious diseases Conclusion: This review provides data on new therapeutic and prophylactic methods for T. gondii infection based on the use of extracts and/or compounds derived from natural products, which have been reported to be useful as alternative treatment options in the last 20 years. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Databáze: | MEDLINE |
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