[Phosphate binders in renal patients: a point estimate from rationale, through evidences to the real world setting].

Autor: Galassi A, Giovenzana ME, Galbiati E, Auricchio S, Colzani S, Scanziani R
Jazyk: italština
Zdroj: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia [G Ital Nefrol] 2016 Jul-Aug; Vol. 33 (4).
Abstrakt: Phosphate binders represent a common intervention in renal patients affected by chronic kidney disease and mineral bone disorder (CKD-MBD). Although counteracting P overload through binders adoption is argued by a physiology-driven approach, the efficacy of this intervention on hard endpoints remains poorly evident. The inconsistencies between rationale and methodological weakness, concerning the clinical relevance of P binding in chronic kidney disease, will be herein discussed with special focus on the need of a multi-factorial treatment against CKD-MBD, which is currently more achievable due to the variety of P binders and the rapid evolution of nutritional therapy, dialysis techniques and nursing science.
Databáze: MEDLINE