Secondary metabolites from Sida rhombifolia L. (Malvaceae) and the vasorelaxant activity of cryptolepinone.

Autor: Chaves OS; Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil., Gomes RA, Tomaz AC, Fernandes MG, das Graças Mendes L Jr, de Fátima Agra M, Braga VA, de Fátima Vanderlei de Souza M
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2013 Mar 01; Vol. 18 (3), pp. 2769-77. Date of Electronic Publication: 2013 Mar 01.
DOI: 10.3390/molecules18032769
Abstrakt: The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-b-D-glucopyranoside (2a) and stigmasterol-3-O-b-D-glucopyranoside (2b), phaeophytin A (3), 17³-ethoxypheophorbide A (4), 13²-hydroxy phaeophytin B (5), 17³-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by ¹H- and ¹³C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time.
Databáze: MEDLINE