| Autor: |
Bhattacharya S; Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA., Labutti JN, Seiner DR, Gates KS |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Nov 15; Vol. 18 (22), pp. 5856-9. Date of Electronic Publication: 2008 Jun 13. |
| DOI: |
10.1016/j.bmcl.2008.06.029 |
| Abstrakt: |
Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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