Relationship between antitumor efficiency of photodynamic therapy with photoditasine and photoenergy density.

Autor: Romanko YS; Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk, Russia. y_romanko@hotmail.com, Tsyb AF, Kaplan MA, Popuchiev VV
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2005 Apr; Vol. 139 (4), pp. 460-4.
DOI: 10.1007/s10517-005-0322-2
Abstrakt: We studied the effect of photodynamic therapy with photoditasine at different protocols of photoenergy exposure on morphofunctional parameters of M-1 sarcoma. It was found that proliferative activity of tumor cells (evaluated by immunostaining for PCNA) nonlinearly decreases after exposure to 150, 300, and 600 J/cm2. The main form of cell death during the early period after photodynamic therapy was direct photocoagulation necrosis caused by destruction of sensitized cell structures and ischemic necrosis developing as a result of alteration of vascular network in the tumors. Photoenergy density was not essential for the intensity of induced apoptosis.
Databáze: MEDLINE