| Autor: |
Romanko YS; Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk, Russia. y_romanko@hotmail.com, Tsyb AF, Kaplan MA, Popuchiev VV |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2005 Apr; Vol. 139 (4), pp. 460-4. |
| DOI: |
10.1007/s10517-005-0322-2 |
| Abstrakt: |
We studied the effect of photodynamic therapy with photoditasine at different protocols of photoenergy exposure on morphofunctional parameters of M-1 sarcoma. It was found that proliferative activity of tumor cells (evaluated by immunostaining for PCNA) nonlinearly decreases after exposure to 150, 300, and 600 J/cm2. The main form of cell death during the early period after photodynamic therapy was direct photocoagulation necrosis caused by destruction of sensitized cell structures and ischemic necrosis developing as a result of alteration of vascular network in the tumors. Photoenergy density was not essential for the intensity of induced apoptosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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