Apolipoprotein E, amyloid, and Alzheimer disease.

Autor: Bales KR; Neuroscience Discovery Research, Lilly Research Laboratories Indianapolis, IN 46285, USA., Dodart JC, DeMattos RB, Holtzman DM, Paul SM
Jazyk: angličtina
Zdroj: Molecular interventions [Mol Interv] 2002 Oct; Vol. 2 (6), pp. 363-75, 339.
DOI: 10.1124/mi.2.6.363
Abstrakt: Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein ( (apoE). The risk that specific isoforms of apoE pose with regard to Alzheimer Disease clearly varies, and so the roles that apoE plays in the brain will be crucial to a full understanding of the disease and to efforts to develop effective therapies.
Databáze: MEDLINE