In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy) propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450 /
The total content of rat liver microsomal cytochrome P450 (CYP) significantly decreased after repeated i.p. administration of the antiviral agent tenofovir ((R)-9-[2-(phosphonomethoxy)propyl] adenine) and tenofovir disoproxil at a daily dose 25 mg/kg, although the content of liver microsomal protein...
| Hlavní autor: |
Anzenbacherová, Eva, 1959-
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Autor )
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| Další autoři: |
Anzenbacher, Pavel, 1947-
(
Autor )
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| Typ dokumentu: | Článek |
| Jazyk: |
angličtina |
| ISSN: | 0862-8408 |
| Zdroj: | Physiological research: Vol. 57, is. 5 (2008), s. 761-767. |
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