Age- and dose-specific anticonvulsant action of bumetanide in immature rats /.
GABA exhibits depolarizing action in the immature neurons due to high intracellular activity of chloride ions. It is maintained by cation-chloride cotransporter NKCC1 which is present in immature brain. Bumetanide is a specific inhibitor of this cotransporter. We studied possible anticonvulsant acti...
| Hlavní autor: |
Mareš, Pavel, 1937-
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Autor )
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| Typ dokumentu: | Článek |
| Jazyk: |
angličtina |
| ISSN: | 0862-8408 |
| Zdroj: | Physiological research: Vol. 58, is. 6 (2009), s. 927-930. |
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