Chapter 2 Protein Folding And Misfolding

Autor: Riemer, Judith-Elisabeth, Panfilova, Diana, Olzscha, Heidi
Jazyk: angličtina
Rok vydání: 2022
Předmět:
ad
age
alejandro
alihamze
anna
arantxa
aspects
assembly
Athanasopouloi
autophagy
between
cell
central
chaerone
chapter
Chondrogianni
complex
concluding
conculsions
contents
control
crosstalk
current
deciphering
definition
degradation
Diana
diseases
during
Efstathios
elF5A
Elah
Elisabeth
Factors
Farras
fathinajafabadi
Ferrando
Ferriz
folding
functions
future
gioran
gonos
heat
heidi
integrity
interplay
introsuction
irreversible
judith
kapetanou
kinetic
leading
localized
Marianna
Martinez
mechanisms
MicroRNAs
misfolding
molecular
motifs
network
Kiki
Olzscha
organellar
other
oxidative
panfilova
pathway
pauses
perspectives
pick
polu
pro
process
Proteasome
protein
proteinopathies
proteolysis
proteome
proteostasis
proteostatic
quality
references
regulation
regulators
related
remarks
rescues
response
reversible
ribosomal
riemer
rosa
RQC
S
shock
significance
sophia
stalling
stress
system
systemic
systems
table
targeting
term
thermodynamic
transcriptional
translation
translational
treatments
ubiquitin
unfolded
thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences
thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry
thema EDItEUR::P Mathematics and Science::PS Biology
life sciences::PSD Molecular biology
thema EDItEUR::P Mathematics and Science::PS Biology
life sciences
Druh dokumentu: chapter
DOI: 10.1201/9781003048138-2
Popis: Proteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies.
Databáze: OAPEN Library
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