Dizajn, sinteza i antiproliferativna aktivnost prirodnih citotoksičnih laktona i analoga

Autor:	Srećo Zelenović Bojana
Jazyk:	srbština
Rok vydání:	2013
Předmět:	Citotoksični laktoni goniofufuron murikatacin kardiobutanolid sinteza analoga SAR antiproliferativna aktivnost Cytotoxic lactones goniofufurone muricatacin cardiobutanolide analogues synthesis SAR antiproliferative activity
Druh dokumentu:	Diplomová práce
Popis:	Ostvarene su višefazne sinteze prirodnih citotoksičnih laktona (+)-murikatacina (1),(–)-murikatacina (ent-1) i (+)-goniofufurona (2), kao i njihovih novih analoga (3a,  4,5,  6,  7,  8,  9,  ent-7 i ent-9), polazeći iz  D-ksiloze ili iz  D-glukoze. Ispitana je  in vitrocitotoksična aktivnost sintetizovanih prirodnih proizvoda i analoga premaodabranim humanim tumorskim ćelijskim linijama (K562, HL-60, Jurkat, Raji, HT-29, MDA-MB 231 i HeLa), kao i prema ćelijama fetalnih fibroblasta pluća (MRC-5). Multiphase synthesis of natural cytotoxic lactones  (+)-muricatacin (1),(–)-muricatacin (ent-1) and (+)-goniofufurone (2), as well as synthesis of theiranalogues (3a,  4,  5,  6,  7,  8,  9,  ent-7and  ent-9) was achived from  D-xylose orD-glucose as starting compounds. In vitro cytotoxic  activity of synthetized naturalproducts and analogues against selected human tumour cell lines (K562, HL-60,Jurkat, Raji, HT-29, MDA-MB 231 and HeLa) and against cells of natural foetal lung fibroblasts (MRC-5) was examined.
Databáze:	Networked Digital Library of Theses & Dissertations
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