Uticaj modela programa vežbanja na koštanu gustinu i biohemijske markere koštanog remodelovanja kod žena u pre- i postmenopauzi

Autor: Marijanac Ana
Jazyk: srbština
Rok vydání: 2018
Předmět:
Druh dokumentu: Diplomová práce
Popis: Generalni cilj ovog istraživanja je da se utvrdi da li postoji uticaj primenjenogprograma vežbanja na parametre koštane gustine i biohemijske markere koštanogremodelovanja kod žena u periodu premenopauze i postmenopauze.Uzorak ispitanica je činilo 26 žena starosti 45 do 55 godina, od kojih su 13 u periodupremenopauze, a 13 u periodu postmenopauze. Ispitanice su učestvovale u programu vežbanjau trajanju od 6 meseci, koji se realizovao u Novom Sadu, 4 puta nedeljno u trajanju od satvremena. Za utvrđivanje uticaja programa vežbanja na koštanu gustinu merena su 3osteodenzitometrijska parametra na kičmi, vratu butne kosti i kuku i 5 parametarabiohemijskih markera koštanog remodelovanja.Da bi se utvrdio uticaj vežbanja kod ispitanica, primenjena je multivarijatna analizevarijanse (MANOVA). Na celokupnom uzorku ispitanica nije utvrđena statistički značajnarazlika ni u jednom merenom parametru koštane gustine. U odnosu na biohemijske markere,došlo je do značajnog smanjenja nivoa ukupne alkalne fosfataze. Kod žena u periodupremenopauze i kod žena u periodu postmenopauze, program vežbanja nije značajno uticaona parametre koštane gustine merene na kičmi, vratu butne kosti i kuku (DXA, LunarProdrigy), kao ni na parametre biohemijskih markera koštanog remodelovanja.Primenom multivarijatne analize kovarijanse (MANCOVA) utvrđena je značajnarazlika u uticaju programa vežbanja između žena u pre- i postmenopauzi u mineralnojkoštanoj gustini vrata butne kosti (BMD VF) i markera beta-crosslaps (CTX). Mineralnakoštana gustina je nakon programa vežbanja veća, a nivo beta-crosslapsa niži kod žena upremenopauzi nego kod žena u periodu postmenopauze.Na osnovu dobijenih rezultata, zaključujemo da je potreban duži vremenski periodrealizacije programa vežbanja kako bi se mogla primetiti statistički značajna promenamerenih parametara. Ispitanicama se savetuje da nastave sa vežbanjem kako bi usporilegubitak kosti
The genaral aim of this research is to determine is there an effects of the applied exerciseprogram on bone mineral density and and biochemical markers of bone turnover in thepremenopausal and postmenopausal period.The sample was consisted of 26 women aged 45 to 55 years, of which 13 were inpremenopausal and 13 in postmenopausal period. Subjects were included (had performing) in 6-monthexercise program, which was implemented (maintained) in Novi Sad, 4 times a week in duration for anhour. Three osteodensitometric parameters on lumbar spine, femoral neck and hip (DXA, LunarProdrigy) and five parameters of biochemical markers of bone turnover were measured to assessed(to determine) the effects of exercise program on bone density.Multivariate analysis of variance (MANOVA) was used to determine the effect of exercise.For the entire sample of subjects, there were no statistically significant difference in any measuredbone density parameter, but looking at biochemical markers, total alkaline phosphatase level weresignificanly reduced. There were no significant changes in bone density parameters on the lumbarspine, femoral neck and hip nor on the parameters of biochemical markers of bone turnover in womenin premenopausal and postmenopausal period.Applying multivariate analyse of covariance it was found a significant difference in theexercise program effect between pre- and postmenopausal women in bone mineral density of femoralneck (BMD VF) and beta-crosslaps marker of turnover (CTX). Femoral neck BMD was higher, andbeta-crosslaps level was lower in premenopausal women than in postmenopausal women aftercompletion exercise program.Based on obtained results, we conclude that is required a longer perod of exercise programralization in order to notice a statistically significant change in measured parameters. Subjects areadvised to continue their exercising in order to slow down the bone loss
Databáze: Networked Digital Library of Theses & Dissertations
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