| Popis: |
Background: Evaluation of acid-base disorders using Stewart-Fencl principle is based on assessment of independent factors: strong ion difference (SID) and the concentration of non- volatile weak acids (Atot-). This approach allows for a more detailed evaluation of the cause of acid-base imbalance than the conventional bicarbonate-centered approach based on the Henderson-Hasselbalch principle. Studies with lactate-based peritoneal dialysis fluid (PDF) demonstrated an effect of peritoneal membrane transport characteristics on acid-base status. The "A" aim of our study was to assess acid-base disorders in peritoneal dialysis (PD) patients using both of these principles. The "T" aims were to determine whether or not peritoneal membrane transport characteristics, i.e., dialysate-to-plasma creatinine ratio (D/Pcreat) and creatinine mass transfer area coefficient (MTACcreat) have an effect on base influx when using a PDF with a combination of bicarbonate (bic-25mmol/L) and lactate (lac-15 mmol/L), and whether or not base influx differ between patients using icodextrin- or glucose-based PDF in night-time exchange. Methods: Two groups of patients with chronic renal failure treated with peritoneal dialysis "A" 17 patients and "T" 21 patients and group of healthy volunteers with normal renal function were... |
