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Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Anita Mulaku Supervisor: Assoc. Prof. Petr Zimčík, Ph.D. Title of Diploma Thesis: Stability evaluation of magnesium complexes of phthalocyanines and azaphthalocyanines under acidic conditions Phthalocyanines are categorized as analogues of porphyrin where the structures is based on four isoindoline units condensed via a nitrogen atom. Alongside subphthalocyanines, these compounds are attracting attention as useful dyes that find application in photodynamic therapy, organic electronic devices, organic solar cells and other areas. Phthalocyanines are capable of forming complexes with different types of metal and can be used in fluorescence probing due to their suitable absorption and emission in the red region of the visible spectrum. Red or near-infrared excitation and emission is important for biological applications since longer wavelength light penetrates deeper into tissues, it is less scattered and the autofluorescence of endogenous chromophores is limited. The photophysical and photochemical properties of phthalocyanines and their analogues depend highly on the central metal and peripheral substitution. The magnesium complexes are highly suitable for the... |
