Imunogenetické a hormonální predispoziční markery systémových revmatických onemocnění,zejména systémového lupus erythematodu
| Autor: | Fojtíková, Markéta |
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| Jazyk: | čeština |
| Rok vydání: | 2011 |
| Předmět: |
Systemic lupus erythematosus
exprese hlavní histokompatibilní systém prolaktin psoriatic arthritis systemic sclerosis prolactin autoimmunity dermatomyositis major histocompatibility system autoimunita psoriatická artritida polymyositis alela alele dermatomyositida rheumatoid arthritis revmatoidní artritida gen association polymorphism polymyositida asociace Systémový lupus erythematodes polymorfismus systémová sklerodermie gene expression |
| Druh dokumentu: | Doctoral Thesis |
| Popis: | Fojtikova 2011 INTRODUCTION: Several factors like genetic susceptibility is required for systemic rheumatic diseases development. Immunomodulatory PRL effect supports autoimmunity. AIMS: 1. To detect the immunogenetic background (alleles HLA class I, II and microsatellite polymorphism of the transmembrane part exon 5 of MIC-A gene) of SLE and PsA. 2. To detect PRL serum and synovial fluid with regard to clinical and laboratory RA activity. 3. To find the role of the functional polymorphism -1149G/T SNP PRL of extrapituitary promoter of PRL gene in SLE, RA, PsA, SSc and inflammatory myopathies development. METHODS: Genetic analyses of pateints with SLE (n=156), RA (n=173), PsA (n=100), SSc (n=75), PM (n=47) a DM (n=68) and 123 healthy individuals: PCR-SSP (HLA clase I and II), PCR-fragment analysis (MIC-A) a PCR-RFLP (-1149 G/T SNP PRL). In 29 RA a 26 OA PRL serum and synovial fluid concentrations were detected using immunoradiometric assay. RESULTS: 1. The allele HLA-DRB1*03 (pc=0.008; OR 2.5) and haplotype HLA-DRB1*03-DQB1*0201 (pc |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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