| Popis: |
2 2. Abstract Cleft palate is one of the most frequent congenital malformations. The complexity of these conditions requires surgical treatment in several stages. The first stage includes reconstruction of the nose and the lip, and timing is either shortly after birth, or, in about two thirds of centers worldwide this surgery is performed at the age of 3 months. The next stage, palate defect repair, is timed at around 9 months of age, and the final reconstruction of the maxilla is done based on the permanent canine eruption at about 8 years of age. The main objective of our study was to estimate the pros and cons of early surgical approach after introducing a novel modified surgical protocol versus the conventional surgical protocol. The 5 main findings include: 1. A novel surgical procedure to repair neonatal cleft lip was developed, incorporating modification of Tennison protocol by adding flaps acquired from the margins of the cleft. An important contribution is a shorter time both under anesthesia and in the theatre, and resulting reduction of hospital stay from 7-8 days down to 3-4 days. 2. We have compared the biochemical parameters of the surgical wound healing - matrix metaloproteases (MMP) and their inhibitors (TIMP) in the group of children having surgery early in neonatal age and in children... |
