| Popis: |
Incidence of heart failure is steadily increasing over the past several decades, partly due to the population aging and improved methods in the treatment of patients with acute coronary syndromes. With regard to the evidence that natriuretic peptides are independent prognostic markers of cardiovascular diseases and reflect actual hemodynamic and clinícal status of the patients with heart failure, an idea has emerged to use natriuretic peptide monitoring in guidance of heart failure therapy. This means to treat heart failure with the goal of decreasing BNP and NT-proBNP plasma levels as low as possible. (...) ln conclusion, in our first study we found out that the treatment strategy of heart failure guided by plasma SNP did not lead to significant reduction of cardiovascular events in comparison with the standard treatment strategy. Nevertheless, we observed trend in favor of the strategy based on SNP. In our second study we described fast and transient rise of plasma SNP concentrations immediately after short-term maximal physical exercise in healthy individuals. However, this rise did not reach pathological values typical for heart failure. We assume that it was probably caused by SNP release from cardiomyocytes storage granules rather than synthesis de novo. |
