Vliv hyaluronanu na transdermální penetraci vybraných léčivých látek

Autor:	Ureš, Tomáš
Jazyk:	čeština
Rok vydání:	2014
Předmět:	kyselina hyaluronová penetrace látek vnitřní viskozita hyaluronan urychlovače transdermální penetrace hyaluronan acid Franzova cela nesteroidní antiflogistika transdermal penetration enhancers non-steroidal anti-inflammatory drugs Franz cell penetration of substances intrinsic viscosity
Druh dokumentu:	masterThesis
Popis:	This work deals with the transmittance of a family of non-steroidal anti-inflammatory drugs across biological membranes in combination with the use of hyaluronan. Hyaluronic acid (hyaluronan, HYA) is a linear polysaccharide formed from disacharide units containing N-acetyl-D-glucosamine and glucuronic acid. HYA is present in almost all biological fluids and tissues, so there is an assumption that could affect the penetration of substances through the skin. Standards were prepared by anti-inflammatory drugs in admixture with various concentrations hyaluronan and subsequently measured transmittance of such substances through the skin. Standards were applied to the skin obtained from pig auricle. The drug content was determined by HPLC.
Databáze:	Networked Digital Library of Theses & Dissertations
Externí odkaz:	http://www.nusl.cz/ntk/nusl-217031 Zobrazit plný text záznamu