Prevalence and risk factors of adverse events during treatment of drug resistant tuberculosis in a setting of high human immunodeficiency virus co-infection in Namibia : 2009-10
| Autor: | Sagwa, Evans Luvaha |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Popis: | Magister Public Health - MPH Namibia is currently coping with a dual burden of human immunodeficiency (HIV) and HIV-associated tuberculosis (TB). In 2010, HIV prevalence was 18.8%, the TB case notification rate was 634 per 100,000 population, while TB/HIV co-infection was 58% in 2009. There were 372 reported cases of drug-resistant TB (DR-TB) in 2009. This study assessed the prevalence, profile and outcome of adverse events (AEs) associated with the treatment of DR-TB, and risk factors for the adverse events. The researcher used a cross-sectional design. Data was collected from the treatment records of all patients treated for DR-TB (N = 59) at the study facility between January 2008 and February 2010. Descriptive statistics were used to describe the frequency of the adverse events and logistic regression to analyse the association between possible risk factors and (specific) adverse events, with stratification (sub-group analysis) and multivariate analysis to adjust for measured confounders. Results of logistic regression analysis are reported as odds ratio (OR), 95% confidence interval (CI) and p-value, where p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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