| Autor: |
Smith, E W, Meyer, E, Haigh, J M, Maibach, H I |
| Jazyk: |
angličtina |
| Rok vydání: |
1991 |
| Druh dokumentu: |
Článek |
| Popis: |
The human skin blanching assay remains in widespread use as a reliable, qualitative, comparative indicator of topical corticosteroid availability and potency. The experimental refinements promulgated by certain researchers in this field have yielded a versatile bioassay for the accurate assessment of new drugs or delivery vehicles. With the increasing appearance of generic topical corticosteroid formulations which compete with trade-name equivalents, the vital importance of this assay in regulatory affairs and assessing bioequivalence has been re-emphasized. It is stressed that if the blanching assay is to be used in this sphere, then multiple-reading trials must be conducted; important registration or clinical decisions cannot be made with any validity from short-term assessments. |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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