Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors
| Autor: | Faridoon, H, Edkins, Adrienne Lesley, Isaacs, Michelle, Mnkandhla, Dumisani, Hoppe, Heinrich C, Kaye, Perry T |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Druh dokumentu: | Článek |
| DOI: | 10.1016/j.bmcl.2016.05.023 |
| Popis: | publisher version Encouraging selectivity and low micromolar activity against HeLa cervical carcinoma (IC50 ⩾ 3.0 μM) and the aggressive MDA-MB-231 triple negative breast carcinoma (IC50 ⩾ 9.6 μM) cell lines has been exhibited by a number of readily accessible 4-(N-benzylamino)cinnamate esters. The potential of the ligands as HIV-1 integrase inhibitors has also been examined. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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