Benefits and harms of Ketamine for management of chronic non-cancer pain
| Autor: | Moradi, Sara |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Druh dokumentu: | Diplomová práce |
| Popis: | Background: Chronic non-cancer pain (CNCP) is a prevalent condition, imposing significant burden on healthcare systems. Ketamine is suggested as a potential intervention for CNCP management. We conducted a systematic review and network meta-analysis to assess ketamine's effects in adults with CNCP. Methods: We searched Medline, Embase, CINAHL, and Cochrane CENTRAL up to January-2024 for randomized trials involving adults with CNCP, comparing ketamine with placebo, usual care, or other interventions. Reviewers independently assessed trial eligibility, extracted data, and evaluated risk-of-bias using the Cochrane tool. A random-effects network meta-analysis was performed. We assessed evidence certainty using GRADE. Results: We included 38 trials, with the following comparisons made between ketamine and placebo, using 0-10 VAS: At Thesis Master of Science (MSc) |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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