Biosynthesis of Lycopodium Alkaloids
| Autor: | Marshall, William D. |
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| Rok vydání: | 2009 |
| Předmět: | |
| Druh dokumentu: | Diplomová práce |
| Popis: | An investigation of the biosynthesis of lycopodine, the major alkaloid of Lycopodium tristachyum, has revealed that L-lysine, but not D-lysine is incorporated into this alkaloid. D-lysine serves as a precursor to pipecolic acid in this species. Sodium malonate has been demonstrated to be a specific precursor to lycopodine, but attempts to verify the postulated intermediacy of piperidineacetic acid. In the elaboration of this alkaloid were unsuccessful. As a means of studying the postulated conversion of lycopodine to annotinine, the major alkaloid of Lycopodium annotinum, specifically labelled 9-14C-lycopodine was synthesized. However the specific incorporation into annotinine of several precursors known to be incorporated into lycopodine could not be demonstrated. Doctor of Philosophy (PhD) |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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