Autor:	Smaltz, Daniel Jonathan
Rok vydání:	2014
Předmět:	Organic chemistry analog antiproliferative DC-45-A1 glycosylation synthesis trioxacarcin
Druh dokumentu:	Thesis or Dissertation
Popis:	The trioxacarcins are structurally complex, highly oxygenated bacterial isolates that potently inhibit the growth of human cancer cells in culture as a consequence of their ability to alkylate guanosine residues of duplex DNA. This dissertation presents a component-based synthetic route to the trioxacarcin structural class, broadly defined, which resulted in fully synthetic routes to trioxacarcin A (1), DC-45-A1 (10), and a diverse collection of analogs. Chemistry and Chemical Biology
Databáze:	Networked Digital Library of Theses & Dissertations
Externí odkaz:	http://dissertations.umi.com/gsas.harvard:11551 http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274279 Zobrazit plný text záznamu