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Neisseria meningitidis is a major cause of meningitis and septicaemia which remain an important concern worldwide. Despite the advances in understanding the pathogenicity of N. meningitidis; its complexity is still not fully elucidated. Noteworthy, while a large number of complete genome sequences are now available, the annotation of each of the genes is incomplete with information either lacking entirely or based only on homology with genes in other species. In searching for novel genes in N. meningitidis strain MC58 that might be involved in the pathogenicity, a putative operon encoded by the genes NMB0342 to NMB0345 was bioinformatically identified and homology-based searches indicated that two of the genes, NMB0342 and NMB0345, have homologues in other pathogenic bacteria. This project was conducted to characterise the role of NMB0345 in meningococcal pathogenesis. |
