Novel routes towards securing human osteoblast maturation for potential orthopaedic applications

Autor: Lancaster, Sarah Tamar
Rok vydání: 2014
Předmět:
Druh dokumentu: Electronic Thesis or Dissertation
Popis: Osteoarthritis is a common condition that affects many men and women globally. The mainstay of treatment is joint replacement, or arthroplasty, however roughly 10% of arthroplasty operations performed in the UK will require revision for 'aseptic loosening', which refers to loosening between the prosthesis and host bone. During revision procedures, it is possible that bone will be lost, for example from the acetabulum during hip arthroplasty revision. There are also some cases, for example fracture non-union or fusion operations, where bone is lost. Therefore a mechanism by which bone repair regeneration may be enhanced has the potential to have widespread applications in orthopaedic surgery.
Databáze: Networked Digital Library of Theses & Dissertations