Investigation into the mechanism of RNA polymerase I inhibition by the anticancer agent 9-hydroxyellipticine

Autor: Andrews, William John
Rok vydání: 2013
Předmět:
Druh dokumentu: Electronic Thesis or Dissertation
Popis: Transcription by RNA polymerase 1 (Pol-1) is the main driving force behind ribosome biogensis, a fundamental cellular process that requires the coordinated transcription of all three nuclear polymerases. Increased Pol-1 transcription, and the concurrent increase in ribosome biogensis has been linked to the high rates of proliferation in many cancers. The ellipticine family contains a number of potent anticancer therapeutic agents with some having progressed to stage 1 and II clinical trial; however the mechanism by which these compounds works remain unclear.
Databáze: Networked Digital Library of Theses & Dissertations