The initiation of double-stranded DNA break repair by an AddAB-type helicase-nuclease
| Autor: | Yeeles, Joseph |
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| Rok vydání: | 2009 |
| Předmět: | |
| Druh dokumentu: | Electronic Thesis or Dissertation |
| Popis: | The DNA of all living organisms is constantly damaged by a wide variety of endogenous and exogenous agents. Double-stranded DNA breaks are particularly toxic and under certain conditions a single break will result in cell death. To preserve genome integrity, double-stranded breaks are faithfully repaired via homologous recombination. Recombinational repair in prokaryotes is generally initiated by a class of enzymes known as helicase-nucleases. These enzymes bind tightly to broken duplex DNA ends and use ATP driven motors to unwind the DNA. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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