| Popis: |
Recent studies have demonstrated the potential of Aspergillus fumigatus to form biofilm structures similar to those identified with Candida albicans. In contrast to the wide berth of knowledge relating to the biology of C. albicans biofilms, relatively little is known regarding the development and morphology of multicellular communities of A. fumigatus. This alternate lifestyle may have profound clinical implications with regard to the pathogenic potential of the organism and the likelihood of successful detection and treatment. A reproducible biofilm model of A. fumigatus was developed using several different substrates, which were used to macroscopically and microscopically investigate the phenotypic attributes and general characteristics of biofilm formation, and to investigate antifungal susceptibility profiles. |
