A novel phosphorylcholine-based nanoparticulate drug delivery system

Autor: Salvage, Jonathan Peter
Rok vydání: 2008
Předmět:
Druh dokumentu: Electronic Thesis or Dissertation
Popis: Phosphorylcholine (PC) based materials have been shown to have increased biocompatibility when compared to more established bio-implantable materials. This has been attributed to the ability of PC to mimic the cell lipid bilayer membrane, resulting in reduced protein adhesion and cellular interaction / activation. PC research has previously focused on the areas of contact lens formulation and medical device coating. This project sought to harness the biomimetic properties of PC to develop novel systems for drug delivery, with the emphasis being focused on microparticulate drug delivery.
Databáze: Networked Digital Library of Theses & Dissertations