Dearomatising cyclisations onto pyridines
| Autor: | Brice, Heloise |
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| Rok vydání: | 2009 |
| Předmět: | |
| Druh dokumentu: | Electronic Thesis or Dissertation |
| Popis: | This thesis details investigations into the dearomatising cyclisation onto pyridines. Studies into the cyclisation of enolate or silyl enol ether nucleophiles onto a pyridine ring are described. Flexible hydrocarbon tethers and tethers incorporating either an oxygen or nitrogen atom were investigated and novel fused 6.5 and 6.6 bicyclic piperidines have been synthesised. A one-pot silyl enol ether or silyl ketene acetal formation and cyclisation procedure has been developed. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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