| Popis: |
Alzheimer's disease (AD) is characterised by cognitive dysfunction and the appearance of ?-amyloid plaques (Ap), localised neuroinflammation and neuronal loss throughout the brain. These features are predominantly found in regions important to cognitive function such as the frontal cortex (FC) and hippocampus. The locus coeruleus (LC) is a main source of noradrenaline (NA) in the brain and released NA plays an important role modulating cognitive processes and may also regulate the inflammatory response. LC degeneration is apparent in the early stages of AD, as are decreased NA concentrations in LC projections regions. The relationship between NA dysfunction and AD pathogenesis remains unclear. |
