| Popis: |
Amyloid beta protein (AP) is found in elevated levels in the brains of individuals with Alzheimer's disease, the increased levels of AP are thought to be a causative factor in the pronounced cortical atrophy that is observed post-mortem. Application of exogenous Apuo at physiological and pathological concentrations did not induce cell death in SH-SY5Y cells, differentiated SH-SY5Y cells nor in primary ortical neurone cultures when viability was measured using the Live/Dead cytotoxicity assay. Therefore, rather than a cytotoxic role of Ap this data suggests a more neuroprotective role. |
