| Autor: |
Lin, Shengtao, Shah, Anant, Hernández-Gil, Javier, Stanziola, Antonio, Harriss, Bethany I., Matsunaga, Terry O., Long, Nicholas, Bamber, Jeffrey, Tang, Meng-Xing |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Druh dokumentu: |
Článek |
| ISSN: |
22135979 |
| DOI: |
10.1016/j.pacs.2017.04.001 |
| Popis: |
We demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration. It is manufactured via a 'microbubble condensation' method. The phase-transition of Cy-droplets can be optically triggered by pulsed-laser illumination, inducing photoacoustic signal and forming stable gas bubbles that are visible with echo-ultrasound in situ. Alternatively, Cy-droplets can be converted to microbubble contrast agents upon acoustic activation with clinical ultrasound. Potentially all modes offer extravascular contrast enhancement because of the sub-micron initial size. Such versatility of acoustic and optical 'triggerability' can potentially improve multi-modality imaging, molecularly targeted imaging and controlled drug release. (C) 2017 The Authors. Published by Elsevier GmbH. |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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