Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications

Autor: Tang, Qi, Liang, Min, Lu, Yi, Wong, Pak, Wilmink, Gerald, Zhang, Donna, Xin, Hao
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Druh dokumentu: Článek
ISSN: 1424-8220
DOI: 10.3390/s16040476
Popis: THz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cells. Cells are transported, trapped and concentrated into the THz exposure region by applying an AC bias signal while the chip maintains a steady temperature at 37 degrees C by resistive heating. We conduct some preliminary experiments on E. coli and T-cell solution and compare the transmission spectra of empty channels, channels filled with aqueous media only, and channels filled with aqueous media with un-concentrated and concentrated cells.
Databáze: Networked Digital Library of Theses & Dissertations