Mild hypothermia delays the development of stone heart from untreated sustained ventricular fibrillation - a cardiovascular magnetic resonance study

Autor: Sorrell, Vincent, Paleru, Vijayasree, Altbach, Maria, Hilwig, Ronald, Kern, Karl, Gaballa, Mohamed, Ewy, Gordon, Berg, Robert
Jazyk: angličtina
Rok vydání: 2011
Druh dokumentu: Článek
ISSN: 1532-429X
DOI: 10.1186/1532-429X-13-17
Popis: BACKGROUND:'Stone heart' resulting from ischemic contracture of the myocardium, precludes successful resuscitation from ventricular fibrillation (VF). We hypothesized that mild hypothermia might slow the progression to stone heart.METHODS:Fourteen swine (27 +/- 1 kg) were randomized to normothermia (group I
n = 6) or hypothermia groups (group II
n = 8). Mild hypothermia (34 +/- 2degreesC) was induced with ice packs prior to VF induction. The LV and right ventricular (RV) cross-sectional areas were followed by cardiovascular magnetic resonance until the development of stone heart. A commercial 1.5T GE Signa NV-CV/i scanner was used. Complete anatomic coverage of the heart was acquired using a steady-state free precession (SSFP) pulse sequence gated at baseline prior to VF onset. Un-gated SSFP images were obtained serially after VF induction. The ventricular endocardium was manually traced and LV and RV volumes were calculated at each time point.RESULTS:In group I, the LV was dilated compared to baseline at 5 minutes after VF and this remained for 20 minutes. Stone heart, arbitrarily defined as LV volume
Databáze: Networked Digital Library of Theses & Dissertations
Externí odkaz: