Isolation and Synthesis of Bioactive Compounds from Plants

Autor:	Eaton, Alexander Lee
Rok vydání:	2015
Předmět:	Natural Products Antiproliferative Antimalarial Anti-inflammatory Trihydroxyalkylcyclohexenones Diterpene Triterpene Bis-5-alkylresorcinol Synthesis
Druh dokumentu:	Dissertation
Popis:	As a part of a continuing search for bioactive compounds with the International Cooperative Biodiversity Group (ICBG), and in collaboration with the Natural Products Discovery Institute of the Institute for Hepatitis and Virus Research (IHVR), twelve plant extracts were investigated for their antiproliferative activity against the A2780 cell line, three plant extracts were investigated for their antimalarial activity against Plasmodium falciparum, and three plant extracts were investigated for their anti-inflammatory activity (PPAR-y inhibition). Bioassay-guided fractionation of extracts led to the identification of four new antiproliferative compounds (2.1-2.3, 3.1), five new anti-inflammatory compounds (6.4a, 6.5a-b, 6.6a, 6.6c), and twenty-eight known compounds from eight of the extracts. In addition, mallotojaponin C, an antimalarial natural product, and derivatives were synthesized and investigated for their antimalarial activity. Ph. D.
Databáze:	Networked Digital Library of Theses & Dissertations
Externí odkaz:	http://hdl.handle.net/10919/64367 Zobrazit plný text záznamu