An approach towards the synthesis of Nakadomarin A and Manzamine A Using Pauson-Khand technology

Autor:	Wells, Charles Eugene
Jazyk:	angličtina
Rok vydání:	2004
Předmět:	Nakadomarin A Total synthesis Manzamine A Pauson-Khand reaction N-alkyl piperidine ABC ring Macrocyclic F ring
Druh dokumentu:	Diplomová práce
Popis:	This dissertation is devoted to our synthetic studies towards the total synthesis of the natural product Nakadomarin A, and Manzamine A using the Pauson-Khand reaction as the key step. Chapter 1 reviews past work using Pauson-Khand technology. Chapter 2 reviews the N-alkyl piperidine family of natural products. Chapter 3 reviews published total syntheses of Manzamine A and Nakadomarin A. Chapter 4 explores our work using the Pauson-Khand reaction to form the ABC rings of Nakadomarin A and subsequent B ring expansion to form the ABC ring core of Manzamine A. Chapter 5 explores our approaches to the furan portion, as well as, our approaches to the macrocyclic F ring. Finally Chapter 6 contains the description of the experiments performed along with relevant analytical data. text
Databáze:	Networked Digital Library of Theses & Dissertations
Externí odkaz:	http://hdl.handle.net/2152/29857 Zobrazit plný text záznamu