| Autor: |
Boman, Karolina, Segersten, Ulrika, Ahlgren, Göran, Eberhard, Jakob, Uhlén, Mathias, Jirström, Karin, Malmström, Per-Uno |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Druh dokumentu: |
Článek |
| DOI: |
10.1186/1471-2490-13-17 |
| Popis: |
BACKGROUND: Low nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to be associated with poor prognosis in several cancer forms e.g. breast, ovarian, colorectal, prostate cancer and malignant melanoma. The aim of this study was to examine the prognostic impact of RBM3 expression in urinary bladder cancer. METHODS: Immunohistochemical RBM3 expression was examined in tumours from 343 patients with urothelial bladder cancer. Chi-square and Spearman's correlation tests were applied to explore associations between RBM3 expression and clinicopathological characteristics. The impact of RBM3 expression on disease-specific survival (DSS), 5-year overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan-Meier analysis and Cox proportional hazards modelling. RESULTS: Reduced nuclear RBM3 expression was significantly associated with more advanced tumour (T) stage (p |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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