Effects of Antiplatelet Therapy on Recurrent Stroke in the Stroke Patients
| Autor: | LI, JIA-SHAN, 李佳珊 |
|---|---|
| Rok vydání: | 2019 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 107 Cerebrovascular disease is the main cause of death and disability in many countries. Many studies have confirmed that ischemia accounts for the highest proportion of stroke types. Most patients with ischemic stroke use antiplatelet drugs to prevent the risk of re-stroke.In CAPRIE trial found Clopidogrel in the prevention of cardiovascular disease and reduce bleeding problems better than the current clinically used Aspirin.This study used patients with ischemic stroke to evaluate the effectiveness of Clopidogrel and Aspirin in re-stroke. The study used retrospective analysis to observe a total of 226 cases from September 1, 2015 to November 20, 2018, with patients with ischemic stroke accompanied by multiple chronic diseases,so in response to the effects of Clopidogrel and Aspirin on the recurrence of stroke, bleeding phenomenon and death cases, The factors of Multimorbidity (such as Hypertension, Diabetes Mellitus, Dyslipidemia, and Chronic kidney disease) were listed as the key research directions. Research data showed that the subjects took Clopidogrel (N=50) and Aspirin (N=176), which lasted 1 year. Cox regression analysis of side effects, the results showed that the rate of recurrent stroke in Clopidogrelgl (6 patients, 12%) was higher than that of Aspirin (17 patients, 9.7%); Aspirin (8 patients, 4.5%) Gastrointestinal hemorrhage was Higher than Clopidogrel (1 patients, 2%), and there was no significant difference; A total of Multimorbidity and side effect Only Diabetes Mellitus had significant correlation with recurrent stroke (p > 0.05) and Chronic kidney disease had a significant correlation with death ( p>0.05), while Hypertension and Dyslipidemia had no significant difference (p < 0.05). This study to understand the effectiveness of Clopidogrel and Aspirin for prevention of recurrence of stroke, this study is consistent with the results of real-world.Clopidogrel and Aspirin are effective in preventing the recurrence of stroke; Aspirin gastrointestinal hemorrhage phenomenon is higher than Clopidogrel. If patients with Diabetes Mellitus and Chronic kidney disease history have side effects, they are associated with significant effect.The most important is to understand the main cause of stroke, medical team give appropriate medication treatment, and do the regular health examination to reduce the risk of recurrent stroke. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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