Intraocular Pressure–Lowering Effect of Cordyceps cicadae Mycelia Extract in a Glaucoma Rat Model
| Autor: | YANG,YA-LAN, 楊雅嵐 |
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| Rok vydání: | 2019 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 107 Glaucoma is one of the world’s leading causes of blindness. Cordyceps cicadae is a well-known and most valued traditional Chinese herbal medicine. The aim of this study is to evaluate the intraocular pressure (IOP)-lowering effect of C. cicadae mycelia extract on the steroid-induced glaucoma rat model. The C. cicadae mycelium was cultured by liquid fermentation technique. The lyophilized samples were further extracted using solvents as water and 95% ethanol. The obtained C. cicadae mycelia extracts (CCME) were obtained after lyophilization. The SD rats used in the study were divided into five groups (n=6): Normal group, control group, positive control group (topical brimonidine instillation therapy), and two groups treated with CCME (aqueous and alcoholic extracts, 50 mg/kg,bw). Except for those in the Normal group, all the rats received a subconjunctival injection of betamethasone to induce high IOP. The elevated IOP varied within the range of 30–40 mmHg in the experimental SD rats identified as having glaucoma. Rats in experimental groups received daily administration of CCME via oral gavage for 28 days. The groups with high IOP at the time of glaucoma induction experienced significant average weight loss. Loss of appetite may have led to weight loss in the animal groups with high IOP. Compared with the control group, a trend of increased average body weight was observed for the groups that received CCM for 4 weeks (p0.05). In summary, Cordyceps cicadae mycelia may be beneficial for preventing or treating glaucoma due to its significant IOP-lowering and antioxidant activities. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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